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  • Title: Prognosis of cerebral vein thrombosis presenting as isolated headache: early vs. late diagnosis.
    Author: Gameiro J, Ferro JM, Canhão P, Stam J, Barinagarrementeria F, Lindgren A, International Study on Cerebral Vein and Dural Sinus Thrombosis investigators.
    Journal: Cephalalgia; 2012 Apr; 32(5):407-12. PubMed ID: 22407654.
    Abstract:
    OBJECTIVE: To analyse the outcome of cerebral venous thrombosis (CVT) patients presenting with isolated headache, specifically to compare isolated headache patients with early vs. late CVT diagnosis. METHOD: In the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) database we compared the outcome of patients with isolated headache and a CVT diagnosed early (≤7 days from onset) vs. late (>7 days). We retrieved 100 patients with isolated headache, 52 patients with early CVT diagnosis (early isolated headache) and 48 with late CVT diagnosis (late isolated headache). RESULTS: Neurological worsening was more frequent within early isolated headache patients (23% vs. 8%) (p = 0.045). At the last follow-up (median 411 days), 93% patients had a complete recovery, and 4% were dead or dependent, with no significant difference between early isolated headache and late isolated headache. CONCLUSION: The outcome of CVT patients with isolated headache diagnosed early or late was similarly favourable, but there was a higher proportion of neurological worsening in the acute phase among early isolated headache patients, who need close neurological monitoring.
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