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  • Title: Copper-catalyzed di- and trifluoromethylation of α,β-unsaturated carboxylic acids: a protocol for vinylic fluoroalkylations.
    Author: He Z, Luo T, Hu M, Cao Y, Hu J.
    Journal: Angew Chem Int Ed Engl; 2012 Apr 16; 51(16):3944-7. PubMed ID: 22407851.
    Abstract:
    Dual action: the Lewis acid CuF(2) ⋅2 H(2)O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.
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