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  • Title: [Epidemiology and physiopathogy of Sjögren's syndrome].
    Author: Fauchais AL, Martel C, Vidal E.
    Journal: Rev Prat; 2012 Feb; 62(2):218-20. PubMed ID: 22408868.
    Abstract:
    Sjögren's syndrome is defined as an autoimmune disease characterized by a progressive sicca syndrome associated with anti-SSA or SSA positivity and/or significant infiltrate at minor salivary gland biopsy. This autoimmune disease is relatively frequent, with a clinical diagnosis among women after the 5 decade. Its physiopathology, complex, associates the intervention of both environmental and genetic factors. Salivary epithelial cell is at the center of the pathological immune response of primary Sjögren's syndrome, characterized by a chronic B cell polyclonal activation potentially leading to the development of B cell lymphoma.
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