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  • Title: Cytotoxic diterpenoids from Sapium insigne.
    Author: Liu HB, Zhang H, Yu JH, Xu CH, Ding J, Yue JM.
    Journal: J Nat Prod; 2012 Apr 27; 75(4):722-7. PubMed ID: 22409148.
    Abstract:
    Chemical investigation into the twigs and leaves of Sapium insigne afforded seven new diterpenoids, sapinsignoids A-G (1-7), together with 10 known diterpenoids. The structures of 1-7 were assigned on the basis of detailed spectroscopic analysis and chemical degradation. Compounds 1-4 exhibited significant cytotoxicity against the A-549 tumor cell line (IC(50) 0.2-1.8 μM), while compounds 1-3 showed moderate cytotoxicity against the HL-60 cell line (IC(50) 2.7-6.5 μM).
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