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  • Title: Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China.
    Author: Li X, Wang H, Jing H, Wang Y, Yu C, Wang J, Liu Z, Graviss EA, Ma X.
    Journal: Int J Tuberc Lung Dis; 2012 May; 16(5):612-4. PubMed ID: 22410186.
    Abstract:
    To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.
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