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  • Title: Enantioselective synthesis of fluorene derivatives by chiral N-triflyl phosphoramide catalyzed double Friedel-Crafts alkylation reaction.
    Author: Wang SG, Han L, Zeng M, Sun FL, Zhang W, You SL.
    Journal: Org Biomol Chem; 2012 Apr 28; 10(16):3202-9. PubMed ID: 22411157.
    Abstract:
    A highly efficient tandem double Friedel-Crafts reaction between indoles and 2-formylbiphenyl derivatives by chiral N-triflyl phosphoramide was realized. Under mild conditions, various 9-(3-indolyl) fluorene derivatives have been obtained in good yield and up to 94% ee. Comparing to their corresponding chiral phosphoric acids, chiral N-triflyl phosphoramides catalyzed reactions led to products with opposite absolute configuration.
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