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  • Title: Houttuynoids A-E, anti-herpes simplex virus active flavonoids with novel skeletons from Houttuynia cordata.
    Author: Chen SD, Gao H, Zhu QC, Wang YQ, Li T, Mu ZQ, Wu HL, Peng T, Yao XS.
    Journal: Org Lett; 2012 Apr 06; 14(7):1772-5. PubMed ID: 22414220.
    Abstract:
    Houttuynoids A-E (1-5), a new type of flavonoid with houttuynin tethered to hyperoside, and their presumed biosynthetic precursor hyperoside (6) were isolated from the whole plant of Houttuynia cordata. Their structures were elucidated by analysis of 1D and 2D NMR. A hypothetical biogenetic pathway for houttuynoids A-E was proposed. Compounds 1-5 exhibited potent anti-HSV (herpes simplex viruses) activity.
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