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  • Title: Antagonism of acetylcholine action in guinea-pig tracheal smooth muscle and epithelium by pirenzepine, 4-DAMP and atropine.
    Author: Orer HS, Guc MO, Rezaki YE, Ilhan M, Kayaalp SO.
    Journal: Arch Int Pharmacodyn Ther; 1990; 305():45-54. PubMed ID: 2241429.
    Abstract:
    Acetylcholine-induced guinea-pig tracheal smooth muscle contraction and epithelium-derived relaxant factor release were evaluated using guinea-pig open tracheal rings and rat anococcygeus muscle bioassay to get insight into the participation of muscarinic receptor subtypes in these responses. There was a significant difference between the two pA2 values obtained in contraction and relaxation experiments for pirenzepine, but no difference was found either for atropine or for 4-DAMP. This difference seems to be due to the participation of M1-receptors in smooth muscle contraction.
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