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  • Title: Total synthesis of exiguamines A and B inspired by catecholamine chemistry.
    Author: Sofiyev V, Lumb JP, Volgraf M, Trauner D.
    Journal: Chemistry; 2012 Apr 16; 18(16):4999-5005. PubMed ID: 22415756.
    Abstract:
    The evolution of a total synthesis of the exiguamines, two structurally unusual natural products that are highly active inhibitors of indolamine-2,3-dioxygenase (IDO), is described. The ultimately successful strategy involves advanced cross-coupling methodology and features a potentially biosynthetic tautomerization/electrocyclization cascade reaction that forms two heterocycles and installs a quaternary ammonium ion in a single synthetic operation.
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