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  • Title: [Secondary autoimmune hemolytic anemia as a result of B19 parvovirus persistence in immunodeficient patients].
    Author: Iaguzhinskaia OE, Fevraleva IS, Elizhbaeva MA, Levina AA, Semenova GM, Bugar' NIu, Tsybul'skaia LM, Varlamova EIu, Shitareva IV, Tsyba NI, Kravchenko SK.
    Journal: Ter Arkh; 2011; 83(12):62-8. PubMed ID: 22416448.
    Abstract:
    AIM: To ascertain informative value of immunological diagnosis of B19 parvovirus in combination with polymerase chain reaction (PCR); to analyse frequency of development of secondary autoimmune hemolytic anemia (AIHA) in immunodeficient patients as a result of virus persistence--persistent infection eliminated only by treatment causing suppression of erythropoiesis. MATERIAL AND METHODS: B19 parvovirus detection was performed in blood serum of 207 subjects: 144 patients with anemia (Hb < 100 g/1) and 500 blood donors. DNA of parvovirus B19 was detected in the sera by PCR, antibodies to this virus--by enzyme immunoassay (EIA). IgG, IgM, IgA and components of compliment Clq, C3 on the surface of erythrocytes were detected by EIA in anemic patients. RESULTS: Parvovirus infection was registered in 30% patients, in 70% the infection was persistent. The latter were diagnosed to have secondary AIHA. CONCLUSION: Combined application of PCR and EIA extends potentialities of diagnosis of infection caused by B19 parvovirus. Persistence of the parvovirus provokes onset of symptomatic hemolytic anemia in immunodeficient patients.
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