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  • Title: Poly(2-dimethylamino ethylmethacrylate)-based polymers to camouflage red blood cell antigens.
    Author: Cerda-Cristerna BI, Cottin S, Flebus L, Pozos-Guillén A, Flores H, Heinen E, Jolois O, Gérard C, Maggipinto G, Sevrin C, Grandfils C.
    Journal: Biomacromolecules; 2012 Apr 09; 13(4):1172-80. PubMed ID: 22416913.
    Abstract:
    Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane surface of red blood cells (RBCs). The electrostatic self-assembly of PDMAEMA on RBCs membrane can be employed for inducing the formation of a polymeric shield camouflaging blood group antigens on RBCs as a valuable strategy for developing "universal RBCs" for blood transfusion. The purpose of this research was to evaluate the camouflaging ability of PDMAEMA homopolymers and PDMAEMA-co-poly(ethylene glycol) copolymers differing in molecular weight and architecture. Surprisingly, the PDMAEMAs caused a partially masking, no masking, and sensitization of the same RBCs population. The MW and architecture of the polymers as well as temperature of PDMAEMA-RBCs treatment influenced the results observed. Herein, the very particular reactivity of PDMAEMAs and RBCs is analyzed and discussed.
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