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  • Title: [Bone replacement using demineralized allogeneic bone in animal experiments].
    Author: Schwarz N, Redl H, Schlag G.
    Journal: Beitr Orthop Traumatol; 1990 Aug; 37(8):445-8. PubMed ID: 2241877.
    Abstract:
    The implantation of bone matrix in muscle bag or trepanation defects of rats with greatest reproducibility will induce osteogenesis and defect healing. The phenomenon of osteo-induction was possible to obtain only in first steps in higher developed mammals. Investigations in nude rats have shown a clear difference in biologic reaction on the matrix of various species. The osteo-regeneration in replacement weak defect of ulnar bone in dogs showed a massive greater reactivity of autogenous spongiosa, whereas bank spongiosa and bone matrix produced not more new bone as the control. An increase of osteoinductive matrix potency is a supposition for practical use in case of severe bone defects.
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