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  • Title: Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung.
    Author: Lammel V, Stoeckle C, Padberg B, Zweifel R, Kienle DL, Reinhart WH, Simon HU.
    Journal: Lung Cancer; 2012 Jun; 76(3):493-5. PubMed ID: 22420949.
    Abstract:
    In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.
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