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  • Title: A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine.
    Author: Horai Y, Koyama A, Miyamura T, Hirata A, Nakamura M, Ando H, Takahama S, Minami R, Yamamoto M, Suematsu E.
    Journal: Fukuoka Igaku Zasshi; 2012 Jan; 103(1):24-8. PubMed ID: 22423500.
    Abstract:
    We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.
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