These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Identification of small non-coding RNAs in the planarian Dugesia japonica via deep sequencing.
    Author: Qin YF, Zhao JM, Bao ZX, Zhu ZY, Mai J, Huang YB, Li JB, Chen G, Lu P, Chen SJ, Su LL, Fang HM, Lu JK, Zhang YZ, Zhang ST.
    Journal: Genomics; 2012 May; 99(5):315-21. PubMed ID: 22425900.
    Abstract:
    Freshwater planarian flatworm possesses an extraordinary ability to regenerate lost body parts after amputation; it is perfect organism model in regeneration and stem cell biology. Recently, small RNAs have been an increasing concern and studied in many aspects, including regeneration and stem cell biology, among others. In the current study, the large-scale cloning and sequencing of sRNAs from the intact and regenerative planarian Dugesia japonica are reported. Sequence analysis shows that sRNAs between 18nt and 40nt are mainly microRNAs and piRNAs. In addition, 209 conserved miRNAs and 12 novel miRNAs are identified. Especially, a better screening target method, negative-correlation relationship of miRNAs and mRNA, is adopted to improve target prediction accuracy. Similar to miRNAs, a diverse population of piRNAs and changes in the two samples are also listed. The present study is the first to report on the important role of sRNAs during planarian Dugesia japonica regeneration.
    [Abstract] [Full Text] [Related] [New Search]