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  • Title: Differential prefrontal and frontotemporal oxygenation patterns during phonemic and semantic verbal fluency.
    Author: Tupak SV, Badewien M, Dresler T, Hahn T, Ernst LH, Herrmann MJ, Fallgatter AJ, Ehlis AC.
    Journal: Neuropsychologia; 2012 Jun; 50(7):1565-9. PubMed ID: 22426205.
    Abstract:
    Movement artifacts are still considered a problematic issue for imaging research on overt language production. This motion-sensitivity can be overcome by functional near-infrared spectroscopy (fNIRS). In the present study, 50 healthy subjects performed a combined phonemic and semantic overt verbal fluency task while frontal and temporal cortex oxygenation was recorded using multi-channel fNIRS. Results showed a partial dissociation for phonemic and semantic word generation with equally increased oxygenation in frontotemporal cortices for both types of tasks whereas anterior and superior prefrontal areas were exclusively activated during phonemic fluency. Also, a general left-lateralization was found being more pronounced during semantic processing. These findings line up with earlier imaging and lesion studies emphasizing a crucial role of the temporal lobe for semantic word production, whereas phonemic processing seems to depend on intact frontal lobe function.
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