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  • Title: A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.
    Author: Matson DR, Demirel PB, Stukenberg PT, Burke DJ.
    Journal: Genes Dev; 2012 Mar 15; 26(6):542-7. PubMed ID: 22426531.
    Abstract:
    The COMA/CENP-H/I kinetochore complex regulates microtubule dynamics at kinetochores. The complex is also required to generate spindle checkpoint signals in both yeast and human cells under conditions where Aurora B activity is compromised. Our data explain why mammalian cells treated with Aurora inhibitors still have a functional spindle assembly checkpoint (SAC), since the checkpoint signals through CENP-H/I/N. The SAC effect from depleting the CENP-H/I/N complex cannot be explained by a weakened SAC signal, and the complex has no role in the SAC response to paclitaxel. We propose a model to explain the differential response of human cells to nocodazole and paclitaxel.
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