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  • Title: Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
    Author: Chosson E, Santoro F, Rochais C, Santos JS, Legay R, Thoret S, Cresteil T, Sinicropi MS, Besson T, Dallemagne P.
    Journal: Bioorg Med Chem; 2012 Apr 15; 20(8):2614-23. PubMed ID: 22429510.
    Abstract:
    The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β-phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory effect towards the polymerization of tubulin. The results yielded some potent cytotoxic compounds with correlated partial antitubulin effect.
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