These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis and antitumor activity of 5,6-dihydro-17-hydroxy icogenin analogs.
    Author: Guan YY, Zheng D, Yan Z, Wang N, Lei PS.
    Journal: Eur J Med Chem; 2012 May; 51():200-5. PubMed ID: 22429911.
    Abstract:
    Four 5,6-dihydro-17-hydroxy icogenin analogs were designed and synthesized. Their in vitro antitumor activities were tested by the standard MTT assay. Compound 22 (IC(50) = 3.38-8.30 μM) and compound 23 (IC(50) = 1.90-9.69 μM) showed potential antitumor activities against the entire tested seven cancer cell lines. The SAR (structure activity relationship) research showed that the introduction of 17-hydroxy lowered the antitumor activity to an extent.
    [Abstract] [Full Text] [Related] [New Search]