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  • Title: Clarifying distal axonal properties of the median nerve.
    Author: Moore D, Menon P, Vucic S.
    Journal: Muscle Nerve; 2012 Apr; 45(4):492-9. PubMed ID: 22431081.
    Abstract:
    INTRODUCTION: Although length-dependent axonal excitability changes have been reported in the median nerve, the mechanisms underlying these changes remain to be further clarified. METHODS: Axonal excitability studies were performed on median nerve at the palm and wrist in 20 healthy controls, with responses recorded over the abductor pollicis brevis. RESULTS: The strength-duration time constant was significantly shorter (palm: 0.35 ± 0.01 ms; wrist: 0.48 ± 0.03 ms; P < 0.001), whereas rheobase was significantly increased (palm: 2.90 ± 1.12 mA; wrist: 2.09 ± 1.11 mA; P < 0.05) at the palm. In addition, there was a significant increase in depolarizing threshold electrotonus at 90-100 ms (P < 0.001) and a reduction in S2 accommodation (P < 0.001) and late subexcitability (P < 0.001) at the palm. The changes in excitability were independent of factors influencing median nerve cross-sectional area. CONCLUSIONS: The present study reveals significant length dependent changes in median nerve excitability which may reflect differences in intrinsic membrane properties.
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