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  • Title: Regulation of GPCR trafficking by RAMPs.
    Author: Bomberger JM, Parameswaran N, Spielman WS.
    Journal: Adv Exp Med Biol; 2012; 744():25-37. PubMed ID: 22434105.
    Abstract:
    AM and CGRP receptors undergo differential intracellular receptor trafficking upon ligand stimulation. Intracellular trafficking of CLR/RAMP receptor complexes is regulated by posttranslational modifications and protein-protein interactions that differ for each cell type. Recent evidence is accumulating to suggest that the RAMP isoform in complex with CLR may play a role in determining the intracellular trafficking and fate of ligand-stimulated receptor complexes. In this chapter, we will review the current literature on mechanisms of regulating receptor trafficking and roles that have been demonstrated for RAMPs in this regulation.
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