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  • Title: [Paraneoplastic retinopathy simulating cone dystrophy with achromatopsia].
    Author: Cogan DG, Kuwabara T, Currie J, Kattah J.
    Journal: Klin Monbl Augenheilkd; 1990 Aug; 197(2):156-8. PubMed ID: 2243476.
    Abstract:
    A 72-year-old woman developed recurrent blindness on exposure to bright light (sunlight). Examination revealed total achromatopsia; bilateral central scotomas, predominant suppression of the cone response by electroretinography, and narrowing of the retinal arteries on ophthalmoscopy. The general examination revealed a pelvic tumor that later proved to be a pleomorphic carcinoma of presumed uterine origin. The patient died of metastatic disease 9 months after the ocular symptoms developed. Histopathologic examination of the eyes revealed loss of the photoreceptors, most extensive in the macular regions, and selective loss of the cones from the rest of the retinas. No ocular metastases of inflammation were found. The changes described are interpreted as paraneoplastic retinopathy of autoimmune origin.
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