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  • Title: Assembly of spirooxindole derivatives containing four consecutive stereocenters via organocatalytic Michael-Henry cascade reactions.
    Author: Albertshofer K, Tan B, Barbas CF.
    Journal: Org Lett; 2012 Apr 06; 14(7):1834-7. PubMed ID: 22436132.
    Abstract:
    A novel organocatalytic strategy for the synthesis of highly substituted spirocyclopentaneoxindoles was developed employing simple nitrostyrenes and 3-substituted oxindoles as starting materials. Michael-Henry cascade reactions, enabled through cinchona alkaloid organocatalysis, provided products in high yield and excellent enantioselectivity in a single step.
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