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  • Title: Correlates of rapid neuroleptic response in male patients with schizophrenia.
    Author: Petrie EC, Faustman WO, Moses JA, Lombrozo L, Csernansky JG.
    Journal: Psychiatry Res; 1990 Aug; 33(2):171-7. PubMed ID: 2243894.
    Abstract:
    Correlates of neuroleptic response latency were assessed in 16 male schizophrenic inpatients during 4 weeks of fixed dose (20 mg/day) haloperidol treatment. Rapid responders showed a mean 40% reduction in Brief Psychiatric Rating Scale (BPRS) positive symptom scores by day 10 of treatment. Rapid responders had significantly lower plasma homovanillic acid (pHVA) concentrations compared to non-rapid responders during week 4 of haloperidol treatment. However, rapid versus non-rapid responders did not differ with respect to demographics, baseline positive or negative BPRS symptom scores, performance on tests of neuropsychological function, or mean plasma haloperidol concentrations.
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