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  • Title: The expression of the phosphatase regenerating liver 3 gene is associated with outcome in patients with colorectal cancer.
    Author: Tamagawa H, Oshima T, Yoshihara K, Watanabe T, Numata M, Yamamoto N, Tuschida K, Shiozawa M, Morinaga S, Akaike M, Masuda M, lmada T.
    Journal: Hepatogastroenterology; 2012 Oct; 59(119):2122-6. PubMed ID: 22440248.
    Abstract:
    BACKGROUND/AIMS: The phosphatase of regenerating liver-3 (PRL-3) is over expressed in several human cancers and associated with tumor progression, invasion and metastasis. However, the correlation between PRL-3 expression and clinical outcome in colorectal cancer (CRC) has not been investigated. This study examined the relationship between the relative expression of the PRL-3 gene to the clinicopathological factors and outcomes in patients with CRC. METHODOLOGY: Surgical specimens of cancer tissue and adjacent normal mucosa were obtained from 202 patients with untreated CRC. The relative expression level of PRL-3 mRNA in cancer and in the normal adjacent mucosa was measured using the quantitative real-time reverse-transcriptase PCR. RESULTS: PRL-3 expression was higher in cancer tissue than in the adjacent normal mucosa. The tumor location and liver metastasis were found to be related to the PRL-3 expression level. The overall survival differed significantly between patients with high PRL-3 expression and those with low expression. CONCLUSIONS: High expression of the PRL-3 gene might be a useful predictor of poor postoperative outcome in patients with CRC.
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