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Title: Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates. Author: Prechter A, Gröger H, Heinrich MR. Journal: Org Biomol Chem; 2012 May 07; 10(17):3384-7. PubMed ID: 22441297. Abstract: The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine.[Abstract] [Full Text] [Related] [New Search]