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  • Title: Mechanisms for hepatoprotective effects of hyaluronidase immobilized by the nanotechnology method of electron-beam synthesis.
    Author: Dygai AM, Zyuzkov GN, Zhdanov VV, Udut EV, Artamonov AV, Bekarev AA, Madonov PG, Kinsht DN, Miroshnichenko LA, Khrichkova TY, Simanina EV, Stavrova LA, Chaikovskiy AV, Markova TS, Minakova MY, Gurto RV.
    Journal: Bull Exp Biol Med; 2011 May; 151(1):74-8. PubMed ID: 22442807.
    Abstract:
    Immobilized hyaluronidase (nanotechnology method of electron-beam synthesis) exhibited high hepatoprotective activity on the model of Cl4-induced hepatitis. This agent produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects were shown to accompany stimulation of multipotent bone marrow precursors, mobilization of these cells into the peripheral blood, and cell migration to the target organ increasing the number of parenchymal progenitor cells in the liver. The mechanisms for targeted migration of progenitor cells suggest a decrease in SDF-1 production by bone marrow stromal cells and increase in the synthesis of this factor by microenvironmental cells of the liver tissue.
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