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  • Title: Synthesis and biological evaluation of (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine.
    Author: Clark JL, Clark CB, Mason JC.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2012 Apr; 31(4):286-92. PubMed ID: 22444191.
    Abstract:
    The novel pyrimidine nucleoside, (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine (1) was synthesized from cytidine in seven steps. The key step in the synthesis was the introduction of the tertiary fluorine at the 3'-position. Compound 1 was evaluated in vitro against several RNA viruses.
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