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  • Title: Evaluation and differential diagnosis of marked, persistent eosinophilia.
    Author: Mejia R, Nutman TB.
    Journal: Semin Hematol; 2012 Apr; 49(2):149-59. PubMed ID: 22449625.
    Abstract:
    High-grade eosinophilia can be a diagnostic dilemma, as the etiologies are extensive and varied. Hypereosinophilic syndromes (HES) are a group of heterogeneous disorders, many of which remain poorly defined. By definition, HES must be distinguished from other disorders with persistently elevated eosinophilia with a defined cause. Although marked eosinophilia worldwide is most commonly caused by helminth (worm) infections, non-infectious causes must be considered, and include drug reactions, malignancies, and immunologic, inflammatory and allergic diseases.
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