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  • Title: Context-specific morphine withdrawal in rats: duration and effects of clonidine.
    Author: Kelsey JE, Aranow JS, Matthews RT.
    Journal: Behav Neurosci; 1990 Oct; 104(5):704-10. PubMed ID: 2244979.
    Abstract:
    Rats previously injected with morphine in a particular environment (paired rats) emitted more withdrawal symptoms in that environment than did rats previously injected with morphine in another environment (unpaired rats) after both 1 day and 5 days of morphine abstinence. Thus, reexposure to an environment previously associated with morphine can elicit context-specific withdrawal even after several days of morphine abstinence. Clonidine (0.06 mg/kg) reduced most of the withdrawal symptoms seen 5 days after morphine abstinence in both the paired and unpaired rats. However, clonidine enhanced many of the withdrawal symptoms in both groups of rats during naltrexone-precipitated withdrawal 1 day after morphine abstinence.
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