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  • Title: The influence of ACE genotype on cardiovascular fitness of moderately active young men.
    Author: Almeida JA, Boullosa DA, Pardono E, Lima RM, Morais PK, Denadai BS, Souza VC, Nóbrega OT, Campbell CS, Simões HG.
    Journal: Arq Bras Cardiol; 2012 Apr; 98(4):315-20. PubMed ID: 22450333.
    Abstract:
    BACKGROUND: The angiotensin I-converting enzyme gene (ACE gene) has been broadly studied as for cardiorespiratory fitness phenotypes, but the association of the ACE genotype to middle-distance running has been poorly investigated. OBJECTIVE: This study investigated the possible influence of Angiotensin-Converting Enzyme (ACE) genotype (I/D) on cardiovascular fitness and middle-distance running performance of Brazilian young males. The validity of VO(2max) to predict the ACE genotype was also analyzed. METHODS: A homogeneous group of moderately active young males were evaluated in a 1,600 m running track test (V1600m; m.min(-1)) and in an incremental treadmill test for VO(2max) determination. Subsequently, the actual and the predicted [(0.177*V1600m) + 8.101] VO(2max) were compared to ACE genotypes. RESULTS: The VO(2max) and V1600m recorded for DD, ID and II genotypes were 45.6 (1.8); 51.9 (0.8) and 54.4 (1.0) mL.kg(-1).min(-1) and 211.2 (8.3); 249.1 (4.3) and 258.6 (5.4) m.min(-1) respectively, and were significantly lower for DD carriers (p< 0.05). The actual and predicted VO(2max) did not differ from each other despite ACE genotype, but the agreement between actual and estimated VO(2max) methods was lower for the DD genotype. CONCLUSION: It was concluded that there is a possible association between ACE genotype, cardiovascular fitness and middle-distance running performance of moderately active young males and that the accuracy of VO(2max) prediction may also depend on the ACE genotype of the participants.
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