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  • Title: Inter-chain acyl transfer reaction in a peptide six-helical bundle: a chemical method for regulating the interaction between peptides or proteins.
    Author: Bai Y, Xue H, Ling Y, Cheng M, Cai L, Liu K.
    Journal: Chem Commun (Camb); 2012 May 07; 48(36):4320-2. PubMed ID: 22451895.
    Abstract:
    An inter-helical acyl transfer specifically occurred between the C-and N-peptides of HIV gp41 after assembly of the six-helical bundle (6HB), forming an inter-helical covalent bond that greatly enhanced 6HB stability. In the reaction, the C-peptide was modified as an acyl donor, and the N-peptide served as an acyl acceptor.
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