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  • Title: Association between proinflammatory responses of respirable silica dust and adverse health effects among dust-exposed workers.
    Author: Zhou T, Rong Y, Liu Y, Zhou Y, Guo J, Cheng W, Wang H, Chen W.
    Journal: J Occup Environ Med; 2012 Apr; 54(4):459-65. PubMed ID: 22453811.
    Abstract:
    OBJECTIVE: To evaluate proinflammatory responses induced by respirable silica dust samples and to analyze the role of those responses in explaining adverse health effects among dust-exposed workers in pottery factoryies and tungsten and tin mines. METHODS: Proinflammatory cytokines of cells were determined after being treated with silica dust samples. Adverse health effects of workers were calculated on the basis of a cohort study. RESULTS: Incidence and mortality of silicosis among tungsten miners were higher than those in other workers. The incidence of interleukin-1β levels was highest in tungsten mines, which was consistent with the incidence of silicosis in tungsten miners. The higher levels of TNF-α and interleukin-6 released from macrophages might be helpful in explaining increased mortalities from lung cancer among tin miners. CONCLUSIONS: Interleukin-1β could be a sensitive biomarker in predicting fibrogenic potential of silica dust and the risk of silicosis among dust-exposed workers.
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