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  • Title: Chronic antihypertensive drug treatment decreases protein kinase C activity in platelets from SHR.
    Author: Takaori K, Inariba H, Itoh S, Inoue T, Kanayama Y, Takeda T.
    Journal: Clin Exp Hypertens A; 1990; 12(6):1063-75. PubMed ID: 2245515.
    Abstract:
    There is evidence that protein kinase C activity in platelets from adult SHR is significantly higher than this activity in age-matched WKY. In the present study, protein kinase C activity in the SHR was measured following antihypertensive drug treatment. Chronic administration of enalapril to SHR for 2 weeks decreased both systolic blood pressure and protein kinase C activity to the levels seen in the WKY. Similar results were obtained in case of chronic treatment of SHR with hydralazine or nifedipine. These results suggest that enhanced protein kinase C activity of SHR can be suppressed by lowering blood pressure by antihypertensive drugs.
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