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  • Title: Au@SiO2 core-shell nanoparticles for laser desorption/ionization time of flight mass spectrometry.
    Author: Zhu X, Wu L, Mungra DC, Xia S, Zhu J.
    Journal: Analyst; 2012 May 21; 137(10):2454-8. PubMed ID: 22457874.
    Abstract:
    In matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), the analysis capability, especially for small molecules, is often compromised by the addition of organic matrices due to the existence of background signals. Herein we report a new detection method on the utility of core-shell nanoparticles (CSNPs) as energy transfer structure in LDI-TOF-MS. The LDI-TOF-MS based on gold-silica core-shell nanoparticles with ultrathin silica shell of 2-4 nm (Au@utSiO(2) CSNPs) was effectively applied to the analysis of many compounds, especially for small functional molecules and polymers, which was more promising than MALDI-TOF-MS.
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