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  • Title: Submucosal tumors of the esophagogastric junction originating from the muscularis propria layer: a large study of endoscopic submucosal dissection (with video).
    Author: Li QL, Yao LQ, Zhou PH, Xu MD, Chen SY, Zhong YS, Zhang YQ, Chen WF, Ma LL, Qin WZ.
    Journal: Gastrointest Endosc; 2012 Jun; 75(6):1153-8. PubMed ID: 22459663.
    Abstract:
    BACKGROUND: Given the high morbidity and mortality rates for surgery and the diminishment of quality of life caused by operative resection of the gastric cardia, a minor invasive treatment without loss of curability is desirable for submucosal tumors (SMTs) of the esophagogastric junction (EGJ). Endoscopic submucosal dissection (ESD) has been used successfully for the removal of esophageal or gastric SMTs; however, the EGJ has been regarded as a difficult location for ESD because of its narrow lumen and sharp angle. OBJECTIVE: To evaluate the clinical impact of ESD for SMTs of the EGJ arising from the muscularis propria layer. DESIGN: Single-center, prospective study. SETTING: Academic medical center. PATIENTS: 143 patients with 143 SMTs of the EGJ originating from the muscularis propria layer. INTERVENTIONS: ESD. MAIN OUTCOME MEASUREMENTS: Complications, en bloc resection rate, local recurrence, and distant metastases. RESULTS: The average maximum diameter of the lesions was 17.6 mm (range 5 - 50 mm). The en bloc resection rate was 94.4% (135/143). All en bloc resection lesions showed both lateral and deep tumor-free margins, including 20 GI stromal tumors. Perforations occurred in 6 patients (4.2%, 6/143), and metal clips were used to occlude the defect. Four pneumoperitoneum and 2 pneumothorax caused by perforations were resolved with nonsurgical treatment. Local recurrence and distant metastasis have not occurred during a 2-year follow-up. LIMITATIONS: Single-center, short follow-up. CONCLUSIONS: ESD appears to be a safe, feasible, and effective procedure for providing accurate histopathologic evaluations, as well as curative treatments for SMTs of the EGJ originating from the muscularis propria layer.
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