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  • Title: Double-stranded oligonucleotides containing 5-aminomethyl-2'-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA.
    Author: Shibata A, Ueno Y, Iwata M, Wakita H, Matsuda A, Kitade Y.
    Journal: Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2681-3. PubMed ID: 22460027.
    Abstract:
    This Letter describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with aminomethyl residues have high affinity for single-stranded DNA or RNA in buffer solutions with and without MgCl(2). Thus, these oligonucleotides would be useful as antisense oligonucleotides for targeting single-stranded RNA through triplex formation.
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