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  • Title: Spinal cord injury: one-year evolution of motor-evoked potentials and recovery of leg motor function in 255 patients.
    Author: Petersen JA, Spiess M, Curt A, Dietz V, Schubert M, EM-SCI Study Group.
    Journal: Neurorehabil Neural Repair; 2012 Oct; 26(8):939-48. PubMed ID: 22460611.
    Abstract:
    BACKGROUND: The description of the natural course of recovery from a spinal cord injury (SCI) with spontaneous improvement of neurological, neurophysiological, and functional measures is an important prerequisite in appraising effects of upcoming interventional therapies. OBJECTIVE: To describe the spontaneous evolution of motor-evoked potentials of the anterior tibial muscle (TA-MEP) and their relation to outcomes of lower extremity motor scores (LEMS) and walking function in patients recovering from an acute SCI. METHODS: TA-MEPs were assessed in 255 SCI subjects within 5 time intervals throughout the first year after SCI with combined neurological and functional measures. Tibial nerve conduction studies were performed to screen for peripheral nerve damage. RESULTS: TA-MEP allowed stratification of SCI according to lesion severity and outcome. As MEP amplitudes increased over 12 months after SCI, this was paralleled by a significant improvement of LEMS and walking function. TA-MEP latencies remained usually stable. CONCLUSION: Clinical outcome and walking function after SCI can be predicted independent of clinical measures by assessment of TA-MEP reflecting corticospinal tract integrity.
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