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  • Title: Rituximab treatment for adult patients with focal segmental glomerulosclerosis.
    Author: Ochi A, Takei T, Nakayama K, Iwasaki C, Kamei D, Tsuruta Y, Shimizu A, Shiohira S, Moriyama T, Itabashi M, Mochizuki T, Uchida K, Tsuchiya K, Hattori M, Nitta K.
    Journal: Intern Med; 2012; 51(7):759-62. PubMed ID: 22466834.
    Abstract:
    We present two cases with steroid-resistant nephrotic syndrome (SRNS) and two cases with steroid-dependent nephrotic syndrome (SDNS) due to focal segmental glomerulonephritis (FSGS) who were treated with a single dose of rituximab (375 mg/m(2)). Although the two cases with SRNS showed no response, the two cases with SDNS achieved complete remission. The patients in whom the peripheral B-cell counts subsequently increased after the administration of rituximab demonstrated a relapse. Rituximab may be an effective treatment agent for SDNS with FSGS and the peripheral B-cell count may be a useful marker in such patients for preventing disease relapse.
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