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  • Title: Heterogeneity of anticitrullinated peptide antibodies and response to anti-tumor necrosis factor agents in rheumatoid arthritis.
    Author: Fisher BA, Plant D, Lundberg K, Charles P, Barton A, Venables PJ, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS).
    Journal: J Rheumatol; 2012 May; 39(5):929-32. PubMed ID: 22467927.
    Abstract:
    OBJECTIVE: To examine fine specificity of anticitrullinated peptide antibodies (ACPA) in relation to responsiveness to anti-tumor necrosis factor (anti-TNF) agents in rheumatoid arthritis (RA). METHODS: Samples from 450 patients with RA treated with anti-TNF agents were analyzed for antibodies to citrullinated α-enolase, vimentin, and fibrinogen peptides. The Disease Activity Score-28 was measured at baseline and 6 months. RESULTS: Both anti-cFib antibodies and the number of citrullinated peptides recognized were associated with a poorer response. These findings were not significant following stratification for anti-cyclic citrullinated peptide 2 antibodies. CONCLUSION: The presence of any ACPA rather than individual ACPA specificities was associated with a poorer response to anti-TNF agents. We suggest that this reflects distinctive differences in the pathogenesis of ACPA-positive and negative RA.
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