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  • Title: Architecture of the spliceosome.
    Author: van der Feltz C, Anthony K, Brilot A, Pomeranz Krummel DA.
    Journal: Biochemistry; 2012 Apr 24; 51(16):3321-33. PubMed ID: 22471593.
    Abstract:
    Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human U1 snRNP. This review provides an overview of our current understanding of the architecture of the spliceosome and the RNA-protein complexes integral to its function, the U snRNPs.
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