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  • Title: Transfusion induced Graft versus host disease - Case report in a 2 year child.
    Author: Naveen KN, Kabbin GM, Kulkarni V, Pai VV, Rao R.
    Journal: Transfus Apher Sci; 2012 Aug; 47(1):17-9. PubMed ID: 22475546.
    Abstract:
    Graft-versus-host disease (GVHD) is a rare, almost always fatal complication of a blood transfusion. It occurs much more commonly after bone marrow transplantation, a setting in which it is less severe-mortality rate of 20-25% following transplantation versus 80-90% when associated with a transfusion. Transfusion associated GVHD occurs in two settings: when the recipient is immunodeficient; and when there is a specific type of partial HLA matching between the donor and recipient. Here we present a case of transfusion associated GVHD which developed when a 2 year old immunocompetent girl was given whole blood which was taken by his father. Inspite of very intense therapy with parental steroids and oral cyclosporine the child succumbed to death.
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