These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of 18F-FDG PET/CT in detecting recurrent gallbladder carcinoma.
    Author: Kumar R, Sharma P, Kumari A, Halanaik D, Malhotra A.
    Journal: Clin Nucl Med; 2012 May; 37(5):431-5. PubMed ID: 22475890.
    Abstract:
    AIM: The present study was aimed to determine the efficacy of integrated FDG PET/CT in patients with gallbladder cancer (GBC) with suspicion of recurrent disease. METHODS: A total of 49 patients (male: 15, female: 34; median age: 52.5 years) with GBC underwent FDG PET/CT for suspected recurrence. A total of 62 PET/CT scans were acquired. Criteria for detection by PET/CT were both a positive FDG uptake and the correct anatomic localization of the tumor. The PET/CT findings were grouped as locoregional disease and metastatic disease. Results of PET/CT were compared with clinical and radiologic follow-up and/or histopathology. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated. Results of PET/CT were also compared with conventional imaging (CI) whenever available. RESULTS: Of 62 PET/CT, 43 (69.4%) were positive and 19 (30.6%) were negative for recurrence. Of 43 positive scans, 41 were true positive and 2 were false positive. Among 19 negative PET/CT scans, 18 were true negative and 1 was false negative. PET/CT showed a sensitivity of 97.6% and specificity of 90% in detecting tumor recurrence. The positive predictive value, negative predictive value, and accuracy were 95.3%, 94.7%, and 95.1%, respectively. Locoregional disease was seen in 16 (37.2%) PET/CT studies, distant metastases were seen in 13 (30.2%), and 14 (32.5%) studies showed both locoregional disease and metastasis. When comparable CI was available, PET/CT showed a better specificity than CI for detection of recurrence. CONCLUSIONS: Integrated FDG PET/CT can detect recurrence in GBC with high sensitivity and specificity. Routine use of PET/CT in these patients will detect recurrence early and change the subsequent management.
    [Abstract] [Full Text] [Related] [New Search]