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  • Title: Moclobemide versus clomipramine in the treatment of depression: a single-centre study, Federal Republic of Germany.
    Author: Funke HJ, Moritz E, Hellstern K, Malanowski H.
    Journal: Acta Psychiatr Scand Suppl; 1990; 360():46-7. PubMed ID: 2248069.
    Abstract:
    Moclobemide was compared with clomipramine for safety and efficacy in 2 groups of 15 patients each with endogenous depression. The drugs were given under double-blind conditions in increasing doses; 1 patient in the moclobemide group dropped out because of lack of efficacy. Mean final improvement on the Hamilton Rating Scale for Depression was 51% in the moclobemide group and 54% in the clomipramine group. Efficacy and tolerance were rated good or very good by 47% (moclobemide) and 53% (clomipramine) (NS). The results indicate that moclobemide is as effective as clomipramine in treating endogenous depression.
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