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  • Title: Binding interaction of 1-(4-methybenzyl)-2-p-tolyl-1H-benzo[d]imidazole with bovine serum albumin.
    Author: Jayabharathi J, Thanikachalam V, Jayamoorthy K, Srinivasan N.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2012 Jul; 93():180-4. PubMed ID: 22481174.
    Abstract:
    A promising benzimidazole derivative 1-(4-methybenzyl)-2-p-tolyl-1H-benzo[d]imidazole (MBTBI) has been synthesized and characterized by single crystal XRD, NMR, mass and IR spectral techniques. The mutual interaction of this benzimidazole derivative (MBTBI) with bovine serum albumin (BSA) was investigated using solution spectral studies. The fluorescence quenching mechanism of BSA by MBTBI was analyzed and the binding constant has been calculated. The binding distance between these two was obtained based on the theory of Forester's non-radiation energy transfer (FRET). The effect of some common ions on the binding constant was also examined.
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