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  • Title: Endo-xylanase GH11 activation by the fungal metabolite eugenitin.
    Author: Andrioli WJ, Damásio AR, Silva TM, da Silva VB, Maller A, Nanayakkara NP, Silva CH, Polizeli ML, Bastos JK.
    Journal: Biotechnol Lett; 2012 Aug; 34(8):1487-92. PubMed ID: 22481300.
    Abstract:
    Eugenitin, a chromone derivative and a metabolite of the endophyte Mycoleptodiscus indicus, at 5 mM activated a recombinant GH11 endo-xylanase by 40 %. The in silico prediction of ligand-binding sites on the three-dimensional structure of the endo-xylanase revealed that eugenitin interacts mainly by a hydrogen bond with a serine residue and a stacking interaction of the heterocyclic aromatic ring system with a tryptophan residue. Eugenitin improved the GH11 endo-xylanase activity on different substrates, modified the optimal pH and temperature activities and slightly affected the kinetic parameters of the enzyme.
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