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  • Title: Alzheimer's disease and the amyloid β-protein.
    Author: Walsh DM, Teplow DB.
    Journal: Prog Mol Biol Transl Sci; 2012; 107():101-24. PubMed ID: 22482449.
    Abstract:
    Alzheimer's disease is a devastating disorder that is estimated to affect more than 25 million people worldwide and for which there are no preventive, disease-modifying, or curative therapies. Substantial evidence indicates that the amyloid β-protein (Aβ) is a seminal factor in disease causation and may be a tractable therapeutic target. The ability of Aβ to self-associate to form oligomeric assemblies appears to underlie the early toxic events that lead to memory impairment and subsequent neurodegeneration. We review here research on Aβ folding, self-assembly, and toxicity, highlighting areas critical for the development of efficacious Aβ-directed therapeutics.
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