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  • Title: Cimetidine suppresses chemically induced experimental hepatic porphyria.
    Author: Marcus DL, Nadel H, Lew G, Freedman ML.
    Journal: Am J Med Sci; 1990 Oct; 300(4):214-7. PubMed ID: 2248274.
    Abstract:
    The ability of cimetidine to reduce the activity of hepatic aminolevulinic acid synthase (ALA-S) was examined in allylisopropyl acetamide (AIA) treated porphyric adult rats. A dose of 20 mg cimetidine/100 gm body weight resulted in a 50% decrease in the AIA-induced hepatic ALA-S activity compared to rats treated with AIA alone. Heme oxygenase activity was decreased 25% compared to rats treated with AIA alone. The effects of AIA and cimetidine on cytochrome P-450 were not additive, suggesting competition for a common site of interaction. The results suggest that cimetidine may prove to be useful in treating porphyria in humans.
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