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  • Title: Immunohistochemical characterization of feline mast cell tumors.
    Author: Mallett CL, Northrup NC, Saba CF, Rodriguez CO, Rassnick KM, Gieger TL, Childress MO, Howerth EW.
    Journal: Vet Pathol; 2013 Jan; 50(1):106-9. PubMed ID: 22492208.
    Abstract:
    Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.
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