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  • Title: Facile fabrication of thermo-responsive and reduction-sensitive polymeric micelles for anticancer drug delivery.
    Author: Jiang X, Li L, Liu J, Hennink WE, Zhuo R.
    Journal: Macromol Biosci; 2012 May; 12(5):703-11. PubMed ID: 22496064.
    Abstract:
    The development of thermo-responsive and reduction-sensitive polymeric micelles based on an amphiphilic block copolymer poly[(PEG-MEMA)-co-(Boc-Cyst-MMAm)]-block-PEG (denoted PEG-P-SS-HP) for the intracellular delivery of anticancer drugs is reported. PTX, as model drug, was loaded into the PEG-P-SS-HP micelles with an encapsulation efficiency >90%, resulting in a high drug loading content (up to 35 wt%). The PTX-loaded PEG-P-SS-HP micelles show slow drug release in PBS and rapid release after incubation with DTT. The PTX-loaded micelles display a better cytotoxic effect than the free drug, whereas empty micelles are found to be non-toxic. The thermo-responsive and reduction-sensitive polymeric micelles described may serve as promising carriers for cytostatic drugs.
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